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Carbidopa; Levodopa; Entacapone tablets

What is this medicine?

CARBIDOPA; LEVODOPA; ENTACAPONE (kar bi DOE pa; lee voe DOE pa; en TA ka pone) is used to treat Parkinson's disease. Carbidopa and entacapone help levodopa to work better.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush, or chew this medicine. Take only one tablet of this medicine at each dose. You can take this medicine with or without food. However, avoid foods that are high in fat, calories, and protein near the time of taking this medicine. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • changes in emotions or moods

  • falling asleep during normal activities like driving

  • fast, irregular heartbeat

  • feeling faint or lightheaded

  • fever

  • hallucinations

  • new or increased gambling urges, sexual urges, uncontrolled spending, binge or compulsive eating, or other urges

  • sore muscles

  • stomach pain

  • trouble passing urine or change in the amount of urine

  • uncontrollable movements of the arms, face, head, mouth, neck, or upper body

  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation

  • headache

  • loss of appetite

  • trouble sleeping

  • upset stomach

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • MAOIs like Marplan, Nardil, and Parnate

This medicine may also interact with the following medications:

  • alcohol

  • ampicillin

  • apomorphine

  • bitolterol

  • certain medicines for sleep or anxiety

  • chloramphenicol

  • cholestyramine

  • dobutamine

  • dopamine

  • droperidol

  • epinephrine

  • erythromycin

  • iron supplements

  • isoproterenol

  • isoniazid, INH

  • linezolid

  • medicines for depression, anxiety, or psychotic disturbances

  • medicines for high blood pressure

  • metoclopramide

  • narcotic medicines for pain

  • norepinephrine

  • papaverine

  • phenytoin

  • probenecid

  • reserpine

  • rifampin

  • warfarin

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • depression or other mental illness

  • diabetes

  • glaucoma

  • heart disease, including history of a heart attack

  • history of irregular heartbeat

  • kidney disease

  • liver disease

  • lung or breathing disease, like asthma

  • narcolepsy

  • sleep apnea

  • stomach or intestine problems

  • an unusual or allergic reaction to levodopa, carbidopa, entacapone other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your health care professional for regular checks on your progress. Tell your health care professional if your symptoms do not start to get better or if they get worse. Do not stop taking except on your health care professional's advice. You may develop a severe reaction. Your health care professional will tell you how much medicine to take.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

When taking this medicine, you may fall asleep without notice. You may be doing activities like driving a car, talking, or eating. You may not feel drowsy before it happens. Contact your health care provider right away if this happens to you.

There have been reports of increased sexual urges or other strong urges such as gambling while taking this medicine. If you experience any of these while taking this medicine, you should report this to your health care provider as soon as possible.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

You may experience a 'wearing off' effect prior to the time for your next dose of this medicine. You may also experience an 'on-off' effect where the medicine apparently stops working for anything from a minute to several hours, then suddenly starts working again. Tell your doctor or health care professional if any of these symptoms happen to you. Your dosage may need adjustment.

A high protein diet can slow or prevent absorption of levodopa. Avoid high protein foods near the time of taking this medicine to help prevent this problem. You may want to eat higher protein foods later in the day or in small amounts. Discuss your diet with your doctor or nutritionist.

Do not take iron supplements within 2 hours of taking this medicine. The iron may decrease the amount of levodopa in your system and decrease the effectiveness of the drug

If you have diabetes, you may get a false-positive result for sugar in your urine. Check with your doctor or health care professional.

This medicine may discolor your urine, saliva or sweat, making it look darker or red in color. This is of no cause for concern. However, this may stain clothing or fabrics.

This medicine may cause a decrease in vitamin B6. You should make sure that you get enough vitamin B6 while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care professional.

You should check your skin often for changes to moles and new growths while taking this medicine. Call your doctor if you notice any of these changes.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2020 Elsevier